Front-line trauma research helping to predict organ failure in critically-injured patients

18 Jul 2017

The life-saving impact of trauma research within the first two hours of severe injury is being demonstrated, with latest findings showing predictive capability for patients that may develop organ failure after injury.

The early study, led by Professor Karim Brohi at Queen Mary University of London’s Centre for Trauma Sciences, also found that there is a specific immune response to trauma shortly after injury.

This finding could help with the development of new therapies for treating trauma patients and improving long-term recoveries and outcomes for these patients.

Our Transform Trauma appeal, launched this week and fronted by the rapper Professor Green, is all about raising vital funds to save lives and improve recoveries for severely-injured trauma patients.

Research such as this - supported by our funding and with your support - is having a transformational impact on patients across the UK. But there is so much more we can do with more funding.

Speaking about this study, Professor Brohi said: “The first minutes or hours after a traumatic injury is a key window where a patient’s immune response may set the trajectory for whether they develop organ failure.

“This phase is very challenging to study due to the complexity and logistics of the emergency environment, but if we can understand the mechanisms that lead to poor outcomes, we may be able to help bring dramatic improvements through better diagnostics and therapeutics.”

Organ failure can be a major problem after suffering traumatic injury, contributing to the number of deaths for those who survive the initial physical incident. There are currently no proven therapies for it.

Speaking about the wider importance of trauma research, Professor Brohi added:

“Our bodies are designed to cope with a certain level of injury. But the kind people are experiencing now, like being hit by a bus or being stabbed, is not something we were never evolved to deal with.

“Understanding the normal response to trauma and what excessive trauma does to the bodies of those surviving who would previously not have lived is one aspect. Some people respond differently to others and being able to explore that more may also lead to new treatments.”

Trauma researchers work in the most high-pressured, sensitive environments – with their work starting within minutes of an individual becoming injured. Findings such as those from this study demonstrate the critical importance of their work.

For more details on this, study, please see here.

To see more about our Transform Trauma appeal and how you can help change lives, visit our Transform Trauma pages:

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